Helen Tippetts References for her lecture on Definitions and Aetiology

PDF list of all further reading and references can be found here.

Select references can be found below

Polder 2004
Neiminen 1995
Khalaf 2014
Fleischmannova 2008
Brook et al. 2002

Dental management of Rapp-Hodgkin syndrome associated with oral cleft and hypodontia

Rapp-Hodgkin syndrome (RHS) is a rare type of autosomal dominant disorder characterized by association of ectodermal dysplasia (ED) with cleft lip/palate. The main features include dry, brittle hair with alopecia in adulthood, dental anomalies (hypodontia, microdontia with delayed eruption, fissured tongue, and retruded maxilla), hypohidrosis, dysplastic nails, and clefting. Palmar-plantar keratoderma is seen frequently. RHS has signs and symptoms that overlap considerably with those of ankyloblepharon-ED-clefting syndrome and ectrodactyly-ED-clefting syndrome. 

The below link takes you to an article that discusses a case of RHS, one of the four members in three generations who had ED with variable degree of involvement of hair, teeth, nail, and sweat glands.

Rapp-Hodgkin Syndrome

Certain genes are related to certain patterns of missing teeth

I could never profess to knowing anything about genetics in any great detail ! In this graphic the two main genes in Hypodontia are illustrated. MSX1 shows a significantly different pattern of tooth loss to PAX9 which is heavily associated with the commonly missing lateral incisors and premolars. Have a read of the below article for more information.  

Orphanet Article on Genes and Hypodontia

Is hypodontia a wholly genetic condition ?

An article in the British Dental Journal from 2007 reviews current knowledge on the aetiological basis for hypodontia as well as various types of presentation and classification. Syndromes that are associated with congenitally missing teeth are also illustrated in a table. Click on the link below for the full article. 

Hypodontia-Is it all in the genes ?

Hypodontia can be treated with adhesive techniques efficiently

Dr Samira Al-Salehi of the Dubai College of Dental Medicine has recently presented a case report illustrating the use of adhesive or 'sticky' dentistry to rehabilitate a patient presenting with mild to moderate hypodontia. A pdf of the article can be accessed on the below link.

Hypodontia Adhesive Techniques