Showing posts with label genes hypodontia. Show all posts
Showing posts with label genes hypodontia. Show all posts

Wednesday 19 October 2016

What congenital anomalies do patients with Downs Syndrome present with ?





A low powered study from Brazil has illustrated some evidence for hypodontia being highly prevalent amongst patients with Downs Syndrome. In this study 96 individuals were clinically and radiographically examined. 

Hypodontia was found to be the most prevalent condition at 36%, followed by microdontia at 10%, conical teeth at 7%. Taurodontic teeth were rarer at 3% with other anomalies such as dens invaginatus 1% of cases. 

The authors concluded that the occurrence of hypodontia was high amongst this patient cohort and is likely to impact on their management not only in their interaction with orthodontics and paediatric dentistry but also with special care dentists managing them in adulthood. 

The link can be found below

http://www.stephenhancocks.com/download.php?op=view_article&article_id=395

Thursday 1 September 2016

Is there a link between ovarian cancer and hypodontia ?

A systematic review by Iavazzo and colleagues revealed a possible link between ovarian cancer and hypodontia although the research associated with this was very weak at best.

In total, 385 patients were included in this study. Control group was present in 3 out of 4 studies (340 patients). Hypodontia was present in 20%. Only in 2 out of 4 studies, the number of missing teeth was mentioned (47 teeth), while the majority of them were either maxillary second premolars or maxillary lateral incisors. 

Unilateral distribution of the missing teeth was present in 28 out of 46 patients, while bilateral distribution of the missing teeth was present in 18 out of 46 patients. The presence of ovarian cancer in the family medical history occurred in 12 out of 33 patients. Only 1 out of 4 studies examined the presence of genes with mutations in the included patients. Based on these findings, the lack of clinical studies was the principal obstacle to clarify the possible predictive value of hypodontia in the early prediction of patients with higher risk of ovarian cancer.

Saturday 6 February 2016

Gremlin gene associated with Hypodontia ! Yes Gremlin !

As a child of the 80's I loved the Gremlins films as well as Back to the Future Indiana Jones etc. So it turns out that there is a Bone Morphogenic Protein antagonist that is known to regulate BMPs in embryogenesis and tissue development. Have a look at the abstract of some research by a group from Thailand.  

Gremlin 2 BMP

Friday 8 January 2016

Certain genes are related to certain patterns of missing teeth

I could never profess to knowing anything about genetics in any great detail ! In this graphic the two main genes in Hypodontia are illustrated. MSX1 shows a significantly different pattern of tooth loss to PAX9 which is heavily associated with the commonly missing lateral incisors and premolars. Have a read of the below article for more information.  





Thursday 24 December 2015

Is there a link between hypodontia and ovarian cancer ?



There is emerging evidence that Hypodontia is a risk marker for Ovarian cancer. Ovarian cancer ranks as the 8th commonest cancer in women and only 30% of patients survive as such it is the 5th leading cause of cancer amongst women. In a recent study 20% of ovarian cancer patients had signs of hypodontia. Please click on the link below which will take you to Anna Yu's presentation from the University of Kentucky.  

Click here for a presentation exploring the link.

Saturday 24 October 2015

Is hypodontia a wholly genetic condition ?

An article in the British Dental Journal from 2007 reviews current knowledge on the aetiological basis for hypodontia as well as various types of presentation and classification. Syndromes that are associated with congenitally missing teeth are also illustrated in a table. Click on the link below for the full article. 

Hypodontia-Is it all in the genes ?