I could never profess to knowing anything about genetics in any great detail ! In this graphic the two main genes in Hypodontia are illustrated. MSX1 shows a significantly different pattern of tooth loss to PAX9 which is heavily associated with the commonly missing lateral incisors and premolars. Have a read of the below article for more information.

Hypodontia or missing teeth can result in crookedness, spaces between teeth and small or malformed teeth. Patients can also present with a reduced amount of jawbone.This is an information resource on the oral condition known as hypodontia (also known as anodontia or oligodontia). There is also useful information for dentists on current research for treatment.
Friday, 8 January 2016
Friday, 1 January 2016
Hypodontia in orthodontically treated children
The frequency of hypodontia in orthodontically treated children, both male and female, and the
association between tooth type, the upper or lower arch, the affected side and Angle’s classification were
studied using interviews, oral, study cast and panoramic radiographic examinations of 212 patients with
a mean age of 12 years 7 months.
A hypodontia frequency of 11.3 per cent was found for the total sample. This was higher than the
incidence of hypodontia reported in other studies of orthodontically treated children. The most frequently
missing teeth were the maxillary lateral incisors, and maxillary and mandibular second premolars. The
missing teeth were more often absent on the right (54.2 per cent) than on the left (45.8 per cent) side, in
both males and females. One tooth was absent in 29.2 per cent of patients, two in 58.5 per cent, but seldom
three or more. Orthodontic space closure was the treatment of choice in 87.5 per cent of the subjects.
Click on the article below for more information.
Saturday, 26 December 2015
What Are The Treatment Options in Patients with Unilateral Congenitally Missing Second Mandibular Premolars?
In this article by Gerassimos Angelopoulos, an orthodontist in Greece, the issue of missing second premolars and the management of the retained deciduous molar is discussed and the relative advantages and disadvantages of each are outlined but not entirely addressed. In my experience retention of the primary molar is a realistic option which obviously depends on the tooth's restorative status and how it relates to the occlusal plane. Where infraocclusion is significant enough to result in an increased chance of caries then extraction may need to be seriously considered. Where the tooth is at an acceptable level in the absence of ankylosis the occlusal surface can be restored to maintain contact with the opposing unit. If the deciduous tooth is extracted resin bonded bridges or implants may be an option if space closure is not possible. Alternatively the patient may just be happy with having a space there with no further elective treatment ! Much a dentists head has been scratched on hypodontia clinics thinking about what the best option may be.
Have a read of an orthodontists view.
Angelopouos on the missing second mandibular premolar
Have a read of an orthodontists view.
Angelopouos on the missing second mandibular premolar
Thursday, 24 December 2015
Is there a link between hypodontia and ovarian cancer ?
There is emerging evidence that Hypodontia is a risk marker for Ovarian cancer. Ovarian cancer ranks as the 8th commonest cancer in women and only 30% of patients survive as such it is the 5th leading cause of cancer amongst women. In a recent study 20% of ovarian cancer patients had signs of hypodontia. Please click on the link below which will take you to Anna Yu's presentation from the University of Kentucky.
Saturday, 24 October 2015
Is hypodontia a wholly genetic condition ?
An article in the British Dental Journal from 2007 reviews current knowledge on the aetiological basis for hypodontia as well as various types of presentation and classification. Syndromes that are associated with congenitally missing teeth are also illustrated in a table. Click on the link below for the full article.
Monday, 21 September 2015
Hypodontia is ideally treated in a multidisciplinary setting- A case report

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Tuesday, 15 September 2015
Hypodontia can be treated with adhesive techniques efficiently

Labels:
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Sunday, 6 September 2015
Baby teeth can be built up to function like adult teeth
The Leeds restorative dentistry group have published a review illustrating how 'baby' teeth can be efficiently built up with white filling material to function like adult teeth. This procedure doesn't require the need for anaesthesia or tooth drilling and can be delivered easily.
Wednesday, 2 September 2015
Patients with Hypodontia have different needs to other patients

Wednesday, 5 August 2015
Which teeth are commonly missing in hypodontia patients ?
Some teeth are more likely to present with Hypodontia than others. Polder in 2004 published a meta-analysis that ill the differences between different teeth and their likelihood of being missing. In the order of most commonly missing moving down to least commonly missing.
- Mandibular second premolar
- Maxillary lateral incisor
- Maxillary second premolar
- Mandibular central incisor
- Mandibular lateral incisor
- Maxillary first premolar
- Mandibular second molar
- Maxillary canine
- Mandibular first molar
- Maxillary Central incisor
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